Hydroxyzine-induced acute generalized exanthematous pustulosis: an uncommon side effect of a common drug

A 67-year-old male patient of stable plaque psoriasis involving less than 10% of body surface area was on treatment with topical steroid and was administered hydroxyzine 10 mg. AGEP is not a variant of pustular psoriasis [2] and the neutrophilic inflammation as a manifestation of AGEP is due to IL-8-producing T cells, and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) which contributes to the recruitment of polymorphonuclear leucocytes (PMN) into the epidermis.