Antibodies to decorin-binding protein B (DbpB) in the diagnosis of Lyme neuroborreliosis in children

Highlights • Antibodies towards three decorin binding protein B (DbpB) variants were evaluated. • DbpB variant from Borrelia garinii performed best both in CSF and serum samples. • Sensitivity of the DbpB ELISA was lower in children than in adults tested earlier. • DbpB test does not seem to improve...

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Veröffentlicht in:	International journal of infectious diseases 2014-11, Vol.28 (C), p.160-163
Hauptverfasser:	Sillanpää, Heidi, Skogman, Barbro H, Sarvas, Heikki, Seppälä, Ilkka J.T, Lahdenne, Pekka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Adolescent Antibodies, Bacterial - analysis Antibodies, Bacterial - blood Antibodies, Bacterial - cerebrospinal fluid Borrelia burgdorferi Group - immunology Borrelia burgdorferi Group - isolation & purification Borrelia burgdorferi sensu lato Child Child, Preschool Children CSF DbpB Humans Infectious Disease Lyme neuroborreliosis Lyme Neuroborreliosis - diagnosis Pulmonary/Respiratory
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Beschreibung
Zusammenfassung:	Highlights • Antibodies towards three decorin binding protein B (DbpB) variants were evaluated. • DbpB variant from Borrelia garinii performed best both in CSF and serum samples. • Sensitivity of the DbpB ELISA was lower in children than in adults tested earlier. • DbpB test does not seem to improve laboratory diagnosis of LNB in children.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2014.07.006