2-Alkyl-4-hydroxyquinolines from a Marine-Derived Streptomyces sp. Inhibit Hyphal Growth Induction in Candida albicans

Four 2-alkyl 4-hydroxyquinoline derivatives ( ⁻ ) were isolated from a semisolid rice culture of the marine-derived actinomycete sp. MBTG13. The structures of these compounds were elucidated by a combination of spectroscopic methods, and their data were in good agreement with previous reports. Compo...

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Veröffentlicht in:Marine drugs 2019-02, Vol.17 (2), p.133
Hauptverfasser: Kim, Heegyu, Hwang, Ji-Yeon, Chung, Beomkoo, Cho, Eunji, Bae, Suhyun, Shin, Jongheon, Oh, Ki-Bong
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Sprache:eng
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Zusammenfassung:Four 2-alkyl 4-hydroxyquinoline derivatives ( ⁻ ) were isolated from a semisolid rice culture of the marine-derived actinomycete sp. MBTG13. The structures of these compounds were elucidated by a combination of spectroscopic methods, and their data were in good agreement with previous reports. Compounds and exhibited weak to moderate antibacterial activity against pathogenic bacteria. Unexpectedly, we found that compound acted as a potent inhibitor of hyphal growth induction in the dimorphic fungus , with an IC value of 11.4 μg/mL. Growth experiments showed that this compound did not inhibit yeast cell growth, but inhibited hyphal growth induction. Semi-quantitative reverse transcription (RT)-PCR analysis of hyphal-inducing signaling pathway components indicated that compound inhibited the expression of mRNAs related to the cAMP-Efg1 pathway. The expression of and mRNAs (hypha-specific genes positively regulated by Efg1, an important regulator of cell wall dynamics) was significantly inhibited by the addition of compound . These results indicate that compound acts on the Efg1-mediated cAMP pathway and regulates hyphal growth in .
ISSN:1660-3397
1660-3397
DOI:10.3390/md17020133