Prognostic value of single‐nucleotide polymorphisms for extranodal natural killer/T‐cell lymphoma: the identification of risk factors in the molecular era

Due to the unique feature that majority of ENKTL patients have involvement of the upper aerodigestive tract (UADT), the commonly used international prognostic index (IPI) system for NHL is not applicable for ENKTL as most of the patients would be divided into the low-risk group [ 2]. [...]an optimal prognostic system for ENKTL remains undefined. Additional analyses showed that combining the SNP classifier with several easily obtainable clinical risk factors in a nomogram outperformed previously reported models (the IPI, the Korean prognostic index [KPI], and the prognostic index of natural killer lymphoma [PINK]). [...]between peripheral blood and tumor sample, a high consistency of the seven identified SNP status was observed. [...]the findings were based on retrospective analysis.