Macrophage immunomodulatory effects of low molecular weight peptides from Mytilus coruscus via NF-κB/MAPK signaling pathways

Macrophage immunomodulatory effects of low molecular weight peptides from Mytilus coruscus via NF-κB/MAPK signaling pathways

[Display omitted] •MCP induced the activation of RAW264.7 macrophages and strengthened the phagocytosis of macrophages.•MCP significantly promoted the generation of ROS, NO and pro-inflammatory factors.•MCP activated macrophages via NF-κB/MAPK signaling pathways.•MCP may serve as a promising immunom...

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Veröffentlicht in:Journal of functional foods 2021-08, Vol.83, p.104562, Article 104562
Hauptverfasser: He, Kang, Zeng, Yu, Tian, Hengqun, Zhang, Zhuangwei, Zhang, Huazhe, Huang, Fangfang, Yu, Fangmiao
Format: Artikel
Sprache:eng
Schlagworte:
Immunomodulatory
Low molecular-weight peptides
MAPKs
Mytilus coruscus
NF-κB
RAW264.7 macrophages
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Zusammenfassung:[Display omitted] •MCP induced the activation of RAW264.7 macrophages and strengthened the phagocytosis of macrophages.•MCP significantly promoted the generation of ROS, NO and pro-inflammatory factors.•MCP activated macrophages via NF-κB/MAPK signaling pathways.•MCP may serve as a promising immunomodulator. The objective of the study was to investigate the immunomodulatory activity of the low molecular weight peptides (
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2021.104562