A green approach for the sustained-intestinal delivery of red chili (Capsicum annum L) extracted capsaicinoids with enhanced bioavailability

[Display omitted] •Intestinal delivery of red chili extracted capsaicinoids with enhanced bioavailability.•Pungency masked food-grade beadlets employing fenugreek galactomannan.•Characterization of beadlets with FTIR, NMR, DSC, powder X-ray diffraction and SEM.•Sustained delivery of self-emulsified capsaicinoid particles for better absorption.•Enhanced bioavailability and anti-obesity effects of capsaicinoids in wistar rats. Intestinal delivery with enhanced bioavailability is of great significance for stomach irritating and pungent bioactive molecules. The present study reports the development of a pungency-masked food-grade microbeadlets for the sustained-intestinal delivery of red chili extracted capsaicinoids using fenugreek galactomannans. Capsaicinoids encapsulated microbeads (CapF) of about 250 to 400 µm were prepared by a gel-phase homogenization, fluid-bed granulation followed by galactomannan coating, and characterized by NMR, FTIR, DSC, PXRD, and SEM as stable, directly compressible, free flowing amorphous beadlets with a tap density of 0.64 ± 0.2 g/mL. Swelling studies, in vitrorelease kinetics and particle size analysis indicated the intestinal delivery of soluble capsaicinoids.Pharmacokinetic studies on Wistar rats revealed enhanced bioavailability (19-fold) of CapF when the area under plasma concentration verses time was compared with that of unformulated capsaicinoids. CapF was safe upon gastric mucosa irritation test and demonstrated significant (P