Common Expression Quantitative Trait Loci Shared by Histone Genes

Common Expression Quantitative Trait Loci Shared by Histone Genes

A genome-wide association study (GWAS) was conducted to examine expression quantitative trait loci (eQTLs) for histone genes. We examined common eQTLs for multiple histone genes in 373 European lymphoblastoid cell lines (LCLs). A linear regression model was employed to identify single-nucleotide pol...

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Veröffentlicht in:International journal of genomics 2017-01, Vol.2017 (2017), p.1-14
Hauptverfasser: Kim, Hanseol, Lee, Chaeyoung, Suh, Yujin
Format: Artikel
Sprache:eng
Schlagworte:
Association analysis
Cancer
Cell cycle
Deoxyribonucleic acid
DNA
DNA methylation
Gene expression
Genome-wide association studies
Genomes
Linkage analysis
Linkage disequilibrium
Lymphoblastoid cell lines
Medical research
Proteins
Quantitative trait loci
RNA polymerase
Single-nucleotide polymorphism
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Zusammenfassung:A genome-wide association study (GWAS) was conducted to examine expression quantitative trait loci (eQTLs) for histone genes. We examined common eQTLs for multiple histone genes in 373 European lymphoblastoid cell lines (LCLs). A linear regression model was employed to identify single-nucleotide polymorphisms (SNPs) associated with expression of the histone genes, and the number of eQTLs was determined by linkage disequilibrium analysis. Additional associations of the identified eQTLs with other genes were also examined. We identified 31 eQTLs for 29 histone genes through genome-wide analysis using 29 histone genes (P
ISSN:2314-436X
2314-4378
DOI:10.1155/2017/6202567