Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer

Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2018-06, Vol.23 (7), p.1578
Hauptverfasser:	Wang, Wenrui, Chen, Tiantian, Xu, Henan, Ren, Baihui, Cheng, Xiaodan, Qi, Rongrong, Liu, Haibo, Wang, Yueyue, Yan, Lei, Chen, Sulian, Yang, Qingling, Chen, Changjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antioxidants Antitumor activity Apoptosis Apoptosis - drug effects Bcl-2 protein Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Cycle - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Curcumin Curcumin - administration & dosage Curcumin - chemistry Cyclin D1 Cyclin-dependent kinase 4 Cytotoxicity Drug Carriers Drug Compounding Efficiency Female Humans Inflammation Lipids - chemistry Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Reactive Oxygen Species - metabolism solid lipid nanoparticle Solubility Stability Surface charge Transmission electron microscopy X-Ray Diffraction
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Zusammenfassung:	Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order to improve the therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; the size was about 40 nm with a negative surface charge. The drug loading and encapsulation efficiency in SLNs reached 23.38% and 72.47%, respectively. The Cur-SLNs showed a stronger cytotoxicity against SKBR3 cells. In vitro cellular uptake study demonstrated a high uptake efficiency of the Cur-SLNs by SKBR3 cells. Moreover, Cur-SLNs induced higher apoptosis in SKBR3 cells, compared to cells treated by free drug. In addition, Western blot analysis revealed that Cur-SLNs could promote the ratio of , but decreased the expression of and . These results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules23071578