Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Honghua ( Carthami flos ) and Xihonghua ( Croci stigma ) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathw...

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Veröffentlicht in:	Scientific reports 2022-08, Vol.12 (1), p.14296-12, Article 14296
Hauptverfasser:	Madikyzy, Malika, Tilegen, Meruyert, Nazarbek, Guldan, Mu, Chenglin, Kutzhanova, Aidana, Li, Xugang, Ma, Cuiping, Xie, Yingqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/45 ACE2 Alkaline phosphatase Angina pectoris Angiotensin-converting enzyme 2 Biology Cardiovascular disease Carthamus tinctorius Cell adhesion & migration Chinese medicine Coronaviruses COVID-19 COVID-19 Drug Treatment Cytokines Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - pharmacology Enzyme kinetics Genes Herbal medicine Herbs Humanities and Social Sciences Humans Kinases Laboratories Medicine, Chinese Traditional Molecular Docking Simulation multidisciplinary Natural products Pharmacology Phosphatase Proteins Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Signal transduction Stigma Traditional Chinese medicine
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Zusammenfassung:	Honghua ( Carthami flos ) and Xihonghua ( Croci stigma ) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-15338-9