Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases

Background. Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities. Objective. To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis. Methods. A retrospective review of 36 patients with GA and 26 with sarcoidosis wa...

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Veröffentlicht in:	Journal of immunology research 2023, Vol.2023, p.4098459-10
Hauptverfasser:	Wu, Ze, Li, Linghui, Qu, Hui, Qi, Rui-Qun, Niu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Collagen Gelatinase B Granuloma Granuloma Annulare - metabolism Granuloma Annulare - pathology Granulomas Humans Immunology Inflammatory diseases Lymphocytes Matrix Metalloproteinase 9 Patients Prediction models Sarcoidosis Sarcoidosis - diagnosis Sarcoidosis - pathology Skin diseases Skin Diseases - metabolism Skin Diseases - pathology Skin lesions Software Statistical analysis
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Zusammenfassung:	Background. Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities. Objective. To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis. Methods. A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model. Results. Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs, P
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2023/4098459