Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer

Common genetic variants associated with lung cancer have been well studied in the past decade. However, only 12.3% heritability has been explained by these variants. In this study, we investigate the contribution of rare variants (RVs) (minor allele frequency

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Veröffentlicht in:	PLoS genetics 2023-09, Vol.19 (9), p.e1010902
Hauptverfasser:	Xu, Jingxiong, Xu, Wei, Choi, Jiyeon, Brhane, Yonathan, Christiani, David C, Kothari, Jui, McKay, James, Field, John K, Davies, Michael P A, Liu, Geoffrey, Amos, Christopher I, Hung, Rayjean J, Briollais, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Bayes Theorem Bayesian analysis Biobanks Biology and Life Sciences Breast cancer Cancer Case-Control Studies Cathepsins Consortia DNA sequencing Exome Sequencing Gastric cancer Gene frequency Genealogy Genes Genetic aspects Genetic diversity Genomes Genotype & phenotype Health care networks Heritability Humans Identification and classification Lung cancer Lung Neoplasms - genetics Medicine and Health Sciences Methods Nucleotide sequencing Oncology, Experimental Physical Sciences Prostate cancer Quality control Research and Analysis Methods Whole genome sequencing
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Zusammenfassung:	Common genetic variants associated with lung cancer have been well studied in the past decade. However, only 12.3% heritability has been explained by these variants. In this study, we investigate the contribution of rare variants (RVs) (minor allele frequency
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1010902