Changes in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018

Changes in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018

Streptococcus pneumoniae continues to cause significant disease burden. Whilst pneumococcal conjugate vaccines (PCV) have substantially reduced this burden, serotype replacement partially negates this success due to increased disease associated with non-vaccine serotypes (NVTs). Continued surveillan...

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Veröffentlicht in:Scientific reports 2022-08, Vol.12 (1), p.13332-13332, Article 13332
Hauptverfasser: Cleary, David W., Jones, Jessica, Gladstone, Rebecca A., Osman, Karen L., Devine, Vanessa T., Jefferies, Johanna M., Bentley, Stephen D., Faust, Saul N., Clarke, Stuart C.
Format: Artikel
Sprache:eng
Schlagworte:
631/326/41/1470
631/326/590/1962
Children
Epidemiology
Genomes
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Surveillance
Vaccines
Whole genome sequencing
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Zusammenfassung:Streptococcus pneumoniae continues to cause significant disease burden. Whilst pneumococcal conjugate vaccines (PCV) have substantially reduced this burden, serotype replacement partially negates this success due to increased disease associated with non-vaccine serotypes (NVTs). Continued surveillance is therefore essential to provide crucial epidemiological data. Annual cross-sectional surveillance of paediatric pneumococcal carriage was started in Southampton, UK following PCV7 roll-out in 2006. Nasopharyngeal swabs were collected from children 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17600-6