A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis
A new nortriterpenoid, 19( )-hydroxyl-wuweizidilactone H ( ), and a sesquiterpene, (6 )- -chamigrenic acid ( ), together with one known nortriterpenoid, wuweizidilactone H ( ), and three known hepatoprotective lignans, micrantherin A ( ), gomisin M₂ ( ) and schizandrin ( ) were isolated from the fru...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2017-11, Vol.22 (11), p.1931 |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new nortriterpenoid, 19(
)-hydroxyl-wuweizidilactone H (
), and a sesquiterpene, (6
)-
-chamigrenic acid (
), together with one known nortriterpenoid, wuweizidilactone H (
), and three known hepatoprotective lignans, micrantherin A (
), gomisin M₂ (
) and schizandrin (
) were isolated from the fruit of
. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of
was confirmed for the first time. In vitro assays, compounds
-
(10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by
-acetyl-
-aminophenol (APAP) in human liver carcinoma (HepG2) cells. |
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| ISSN: | 1420-3049 1420-3049 |
| DOI: | 10.3390/molecules22111931 |