Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2011-08, Vol.16 (8), p.6747-6757
Hauptverfasser: Nakano, Toshiki, Yagi, Yusuke, Miyahara, Mizuki, Kaminura, Akio, Kawatsura, Motoi, Itoh, Toshiyuki
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Alcohols - chemistry
Amino acids
Bacterial Proteins - metabolism
Biological Products - chemical synthesis
Catalysis
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Enzymes
Esterification
Fungal Proteins - metabolism
Kinetics
lipase
Lipase - metabolism
Magnetic Resonance Spectroscopy
nitro alcohol
optically active
Plant Proteins - metabolism
Protocol
quaternary chiral carbon
Stereoisomerism
synthesis
Temperature
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules16086747