Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples

Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples

A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in...

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Veröffentlicht in:Emerging infectious diseases 2021-08, Vol.27 (8), p.2212-2214
Hauptverfasser: Hagbom, Marie, Lin, Jenny, Falkeborn, Tina, Serrander, Lena, Albert, Jan, Nordgren, Johan, Sharma, Sumit
Format: Artikel
Sprache:eng
Schlagworte:
Causes of
Diagnosis
Disease transmission
Dispatch
Epidemics
Ethics
Feces
Gastroenteritis
Gastrointestinal surgery
Genetic aspects
Genotype & phenotype
human intestinal enteroids
in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
Infections
infectivity
Norovirus
Norwalk virus
Physiological aspects
Risk factors
RNA virus infections
Values
Virus research
Viruses
vomit
Vomiting
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Beschreibung
Zusammenfassung:A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2708.210011