Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their sp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2012-12, Vol.17 (12), p.15013-15021
Hauptverfasser:	Wang, Qiuhong, Wang, Changfu, Zuo, Yueming, Wang, Zhibin, Yang, Bingyou, Kuang, Haixue
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - toxicity Anesthesia Animals Apoptosis - drug effects Carbon Chinese medicine germacrane-type sesquiterpenoids heishuixiecaoline Investigations lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Neurotoxicity PC 12 cell PC12 Cells Plant Roots - chemistry Rats Rhizome - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Valerian - chemistry Valeriana amurensis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules171215013