RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER

RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER

Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a comple...

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Veröffentlicht in:Sibirskiĭ onkologicheskiĭ zhurnal 2017-09, Vol.16 (4), p.103-107
Hauptverfasser: Gorodnova, T. V., Baranov, S. B., Shevkunov, L. N., Tyatkov, S. A., Sokolenko, A. P., Kotiv, C. B., Imyanitov, E. N., Berlev, I. V.
Format: Artikel
Sprache:eng ; rus
Schlagworte:
dna repair
ovarian cancer
platinum-based chemotherapy
radiotherapy
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Zusammenfassung:Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case.
ISSN:1814-4861
2312-3168
DOI:10.21294/1814-4861-2017-16-4-103-107