Lineages Derived from Cryptococcus neoformans Type Strain H99 Support a Link between the Capacity to Be Pleomorphic and Virulence

Lineages Derived from Cryptococcus neoformans Type Strain H99 Support a Link between the Capacity to Be Pleomorphic and Virulence

The pathogenic yeast Cryptococcus neoformans causes nearly 200,000 deaths annually in immunocompromised individuals. Cryptococcus cells can undergo substantial morphological change during mammalian infection, including increased capsule and cell size, the release of shed capsule, and the production...

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Veröffentlicht in:mBio 2022-04, Vol.13 (2), p.e0028322-e0028322
Hauptverfasser: Fernandes, Kenya E, Fraser, James A, Carter, Dee A
Format: Artikel
Sprache:eng
Schlagworte:
Acetyltransferases - genetics
Animals
Cryptococcosis
Cryptococcus neoformans
Epigenesis, Genetic
giant cells
Histones - genetics
Humans
Mammals
microcells
Mycology
pleomorphism
Research Article
SAGA complex
Virulence
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Zusammenfassung:The pathogenic yeast Cryptococcus neoformans causes nearly 200,000 deaths annually in immunocompromised individuals. Cryptococcus cells can undergo substantial morphological change during mammalian infection, including increased capsule and cell size, the release of shed capsule, and the production of titan (>10 μm), micro (
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.00283-22