MATERNAL and FOETAL OUTCOME IN PREGNANT LADIES HAVING ACUTE HEPATITIS E

Background: Hepatitis E virus affects young people and females in the child bearing age. This study was conducted to determine the maternal & foetal outcome in pregnant ladies with acute hepatitis E. Material & Methods: This cross sectional study was conducted at Khyber Teaching Hospital, Peshawar, from September 2013 to December 2014. Sixty patients with serologically proven evidence of acute hepatitis E virus infection and pregnancy admitted in gynecology & obstetrics ward and medical units were included in this study. All these patients were extensively studied and followed with liver function tests and coagulation profile. Maternal morbidity and mortality were recorded. After that maternal outcomes of these pregnancies were analyzed. Results: Of the sixty cases, 5(8.3%) had miscarriages, 55(91.61%) were delivered, 39(65%) had preterm delivery and 16(26.66%) were delivered at term. Postpartum hemorrhage occurred in 18(30%), Disseminated intravascular coagulation 13(21.66%), Premature rupture of membranes 12(20%). Antepartum Hemorrhage 12(20%), vertical transmission took place in 20(33%) cases. Similarly acute liver failure occurred in 10(16.66%) patients. Maternal mortality took place in 16(26.66%). Conclusion: Hepatitis E virus is major cause of acute hepatitis in women having pregnancy and having adverse maternal outcomes in these pregnancies.