METHODS OF STABILIZATION OF DRUG SUBSTANCES AND THEIR METABOLITES IN BIOLOGICAL FLUIDS DURING BIOANALYTICAL STUDY (REVIEW)

METHODS OF STABILIZATION OF DRUG SUBSTANCES AND THEIR METABOLITES IN BIOLOGICAL FLUIDS DURING BIOANALYTICAL STUDY (REVIEW)

This article describes main methods of preventing degradation of chemically unstable drugs and their metabolites in biological fluids during storage after collection from patients. It is necessary for accurate quantitative determination of these compounds.

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Veröffentlicht in:Razrabotka i registraciâ lekarstvennyh sredstv (Online) 2019-01 (2), p.246-250
Hauptverfasser: I. I. Yaichkov, A. L. Khokhlov, Y. A. Dzhurko, L. N. Shitov, A. A. Trubnikov
Format: Artikel
Sprache:rus
Schlagworte:
bioequivalence
pharmacokinetics
stabilization
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Zusammenfassung:This article describes main methods of preventing degradation of chemically unstable drugs and their metabolites in biological fluids during storage after collection from patients. It is necessary for accurate quantitative determination of these compounds.
ISSN:2305-2066
2658-5049