Five New Biphenanthrenes from Cremastra appendiculata

Five New Biphenanthrenes from Cremastra appendiculata

Five new biphenanthrenes, cremaphenanthrenes A-E (1-5), along with six known ones, were isolated from the ethanolic extract of the tubers of Cremastra appendiculata (D. Don) Makino (Orchidaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. All the compounds obt...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2016-08, Vol.21 (8), p.1089
Hauptverfasser: Liu, Liang, Li, Jun, Zeng, Ke-Wu, Jiang, Yong, Tu, Peng-Fei
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
biphenanthrene
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cremastra appendiculata
cytotoxic activity
Drug Screening Assays, Antitumor
HCT116 Cells
HeLa Cells
Humans
Molecular Structure
Orchidaceae - chemistry
Phenanthrenes - chemistry
Phenanthrenes - pharmacology
Plant Tubers - chemistry
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Zusammenfassung:Five new biphenanthrenes, cremaphenanthrenes A-E (1-5), along with six known ones, were isolated from the ethanolic extract of the tubers of Cremastra appendiculata (D. Don) Makino (Orchidaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. All the compounds obtained were tested in vitro for cytotoxic activities against colon (HCT-116), cervix (Hela), and breast (MDA-MB-231) cancer cell lines. They all showed moderate or weak cytotoxicities to the above cancer cell lines.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21081089