Metabolic Phenotype and Adipose Tissue Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, a...

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Veröffentlicht in:	Mediators of Inflammation 2010-01, Vol.2010 (2010), p.90-98
Hauptverfasser:	Brusik, Miroslav, Klimes, Iwar, Tkac, Ivan, Gasperikova, Daniela, Tkacova, Ruzena, Skyba, Peter, Stroffekova, Katarina, Kurdiova, Timea, Joppa, Pavol, Ukropec, Jozef, Pobeha, Pavol, Ukropcova, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - pathology Adipose tissues Aged Antigens, CD - genetics Antigens, Differentiation, Myelomonocytic - genetics bcl-2-Associated X Protein - genetics Biological and medical sciences Cachexia - complications Cachexia - genetics Cachexia - metabolism Cachexia - pathology Caspase 3 - genetics Chronic obstructive pulmonary disease, asthma Complications and side effects Female Gene Expression General aspects Genetic aspects Health aspects Humans Inflammation Inflammation - pathology Inflammation Mediators - metabolism Insulin Resistance - physiology Interleukin-6 - genetics Lung diseases, Obstructive Male Medical sciences Metabolic Syndrome - complications Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Middle Aged Obesity - complications Obesity - genetics Obesity - metabolism Obesity - pathology Overweight - complications Overweight - genetics Overweight - metabolism Overweight - pathology Panniculitis - complications Panniculitis - genetics Panniculitis - metabolism Panniculitis - pathology Phenotype Physiological aspects Pneumology Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Receptors, Tumor Necrosis Factor, Type I - genetics Tumor Necrosis Factor-alpha - genetics
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Zusammenfassung:	Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3±7.2 years). With increasing body mass index, increases in AT expressions of IL-6, TNF-α, and CD68 were observed (P
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2010/173498