Exosome-hydrogels loaded with metal-organic framework improve skin aging by inhibiting oxidative stress

Solvothermal reactions of Ba(NO with 1,3,5-benzenetricarboxylic acid gave rise to a new coordination polymer of [Ba (BTC) (H O) ]}n ( H3BTC = benzenetricarboxylic acid). The complex was characterized soundly by Fourier transform infrared (FT-IR) spectroscopy, elemental analysis (EA), single-crystal X-ray diffraction (SCXRD), and thermogravimetric analysis (TGA). The framework of has high thermal stability and shows intense luminescence at room temperature. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) have good biocompatibility, based on the chemical synthesis method, the HA/CMCS hydrogel was prepared. With exosomes as drug models, we further synthesized novel exosome-loaded metal gel particles and evaluated their effects on oxidative stress in human dermal fibroblasts.