Synthesis of Hafnium(IV) Polyaminoacetates

Synthesis of Hafnium(IV) Polyaminoacetates

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediam...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2021-06, Vol.26 (12), p.3725
Hauptverfasser: Shulyak, Alexandra T., Bortnikov, Evgeniy O., Kubasov, Alexey S., Selivanov, Nikita A., Lipengolts, Alexey A., Zhdanov, Andrey P., Bykov, Alexander Yu, Zhizhin, Konstantin Yu, Kuznetsov, Nikolai T.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Chloride
complexonates
contrast agent
Contrast agents
coordination chemistry
Crystal structure
Dichlorides
DTPA
Ethylenediamine
Hafnium
Ligands
Nitrilotriacetic acid
Salt
Salts
Single crystals
Sodium
structure elucidation
Toxicity
X-ray diffraction
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Zusammenfassung:The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,N′-tetraacetic acid (dpta), and N-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na2[Hf(NTA)2]·3H2O (1), Na[HfDTPA]·3H2O (2), [HfCDTA(H2O)2] (3), and Na[Hf2(dpta)2]·7.5H2O·0.5C2H5OH (4) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H2O)2] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26123725