Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Hyperoside is an active ingredient in plants, such as in Hypericaceae, in Rosaceae and in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyper...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-05, Vol.27 (9), p.3009
Hauptverfasser: Xu, Sijin, Chen, Shuaipeng, Xia, Wenxin, Sui, Hong, Fu, Xueyan
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Aquatic plants
Blood vessels
Cell growth
Cervical cancer
Crataegus - chemistry
Fermentation
Gene expression
Hypericum - chemistry
hyperoside
Kidneys
Kinases
Lung cancer
Lymphoma
Nanoparticles
Pharmacokinetics
Pharmacology
Polygonum
Proteins
Quercetin - analogs & derivatives
Quercetin - pharmacology
Review
structure
Survival analysis
Toxicity
Transcription factors
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Beschreibung
Zusammenfassung:Hyperoside is an active ingredient in plants, such as in Hypericaceae, in Rosaceae and in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney. However, long-term application of high-dose hyperoside should be avoided in clinical practice because of its renal toxicity. This review summarises the structure, synthesis, pharmacology, pharmacokinetics and toxicity of hyperoside.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27093009