Poor CD4 recovery and risk of subsequent progression to AIDS or death despite viral suppression in a South African cohort

Introduction The prognostic role of CD4 response in the first six months of treatment in patients achieving early viral suppression during HIV treatment is unclear. Methods This was a cohort study of HIV‐positive adults initiating antiretroviral therapy (ART) between April 2004 and August 2007 who a...

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Veröffentlicht in:	Journal of the International AIDS Society 2014-01, Vol.17 (1), p.18651-n/a
Hauptverfasser:	Takuva, Simbarashe, Maskew, Mhairi, Brennan, Alana T, Long, Lawrence, Sanne, Ian, Fox, Matthew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult AIDS AIDS (Disease) Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs antiretroviral therapy CD4 cell count CD4 Lymphocyte Count - statistics & numerical data Collaboration Development and progression discordance Disease Progression Female Glycoproteins Health aspects Highly active antiretroviral therapy HIV HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - mortality Human immunodeficiency virus Humans immunologic response Male Middle Aged Mortality Patient outcomes Prognosis Proportional Hazards Models Risk factors South Africa - epidemiology Studies Time Factors Treatment Outcome Viral Regulatory and Accessory Proteins - drug effects viral suppression Young Adult
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Zusammenfassung:	Introduction The prognostic role of CD4 response in the first six months of treatment in patients achieving early viral suppression during HIV treatment is unclear. Methods This was a cohort study of HIV‐positive adults initiating antiretroviral therapy (ART) between April 2004 and August 2007 who achieved viral suppression (
ISSN:	1758-2652 1758-2652
DOI:	10.7448/IAS.17.1.18651