Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these...

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Veröffentlicht in:International Journal of Endocrinology 2015-01, Vol.2015 (2015), p.207-214-022
Hauptverfasser: Carvalho, André Lopes, Ward, Laura Sterian, Geloneze, Bruno, Etchebehere, Elba C. S., Cavalari, Camila Ayume Amano, Cunha, Lucas Leite, Martins, Mariana Bonjiorno, de Almeida, Jacqueline Fatima Martins, Calixto, Antonio Ramos, Marcello, Marjory Alana, Assumpção, Ligia Vera Montalli da
Format: Artikel
Sprache:eng
Schlagworte:
Blood & organ donations
Body mass index
Cytokines
Deoxyribonucleic acid
Disease
DNA
Endocrinology
Gene expression
Genetic aspects
Genetic polymorphisms
Genetic testing
Leptin
Metastasis
Obesity
Physiological aspects
Questionnaires
Risk factors
Software
Statistical analysis
Thyroid cancer
Tumor necrosis factor-TNF
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Zusammenfassung:Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22±0.98 ng/mL) than those with AG genotype (10.07±0.60 ng/mL; P=0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05±0.59 ng/mL) than the subjects with GG genotype (9.52±0.79 ng/mL; P
ISSN:1687-8337
1687-8345
DOI:10.1155/2015/173218