Efficacy and safety of switching to dolutegravir/lamivudine in virologically suppressed people with HIV-1 aged ≥ 50 years: week 48 pooled results from the TANGO and SALSA studies

As the population of people with HIV ages, concerns over managing age-related comorbidities, polypharmacy, immune recovery, and drug-drug interactions while maintaining viral suppression have arisen. We present pooled TANGO and SALSA efficacy and safety results dichotomized by age (

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Veröffentlicht in:	AIDS research and therapy 2024-03, Vol.21 (1), p.17-9, Article 17
Hauptverfasser:	Walmsley, Sharon, Smith, Don E, Górgolas, Miguel, Cahn, Pedro E, Lutz, Thomas, Lacombe, Karine, Kumar, Princy N, Wynne, Brian, Grove, Richard, Bontempo, Gilda, Moodley, Riya, Okoli, Chinyere, Kisare, Michelle, Jones, Bryn, Clark, Andrew, Ait-Khaled, Mounir
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age groups Aging Anti-HIV Agents - adverse effects Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Biomarkers Body mass index CD4 antigen CD8 antigen Comorbidity Diagnosis Dosage and administration Drug dosages Drug interaction Drug therapy DTG/3TC Effectiveness Female Hepatitis Heterocyclic Compounds, 3-Ring - adverse effects HIV HIV infection HIV Infections - drug therapy HIV Seropositivity - drug therapy HIV-1 Human immunodeficiency virus Humans Lamivudine Lamivudine - adverse effects Male Oxazines Piperazines Polypharmacy Population studies Pyridones Ribonucleic acid RNA Safety Single-tablet regimen Switching Testing
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Beschreibung
Zusammenfassung:	As the population of people with HIV ages, concerns over managing age-related comorbidities, polypharmacy, immune recovery, and drug-drug interactions while maintaining viral suppression have arisen. We present pooled TANGO and SALSA efficacy and safety results dichotomized by age (
ISSN:	1742-6405 1742-6405
DOI:	10.1186/s12981-024-00604-9