Expression of PEDF and VEGF in corneal neovascularization after corneal alkali burn

AIM: To analyze the effect of human amniotic homogenate extract on corneal neovascularization after corneal alkali burn in the process of pigment epithelium derived factor(PEDF)and vascular endothelial growth factor(VEGF)expression and the effect of corneal neovascularization. METHODS: Totally 32 pa...

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Veröffentlicht in:Guo ji yan ke za zhi 2017-08, Vol.17 (8), p.1437-1440
Hauptverfasser: Shu-Yu Zhao, Xiao-Nan Guo, Jin-Xian He
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Sprache:chi ; eng
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Zusammenfassung:AIM: To analyze the effect of human amniotic homogenate extract on corneal neovascularization after corneal alkali burn in the process of pigment epithelium derived factor(PEDF)and vascular endothelial growth factor(VEGF)expression and the effect of corneal neovascularization. METHODS: Totally 32 patients with corneal alkali burn were selected from June 2015 to June 2016 in Foshan, and were randomly divided into Group A and Group B, with a total of 37 eyes. Group A of 17 cases, with a total of 19 eyes, were treated with 40mg/L human amniotic homogenate extract; Group B(n=15), and 18 eyes, treated with 3g/L prednisolone eye drops. In the treatment of 1, 4, 7, 14, 21 and 28d at different time points, we observed the growth of corneal neovascularization, and detected the expression of PEDF and VEGF during angiogenesis. RESULTS: Group A of patients in the use of human amniotic homogenate extract after the treatment, the expression level of PEDF was significantly higher than that in Group B(P=0.001), after 28d treatment, the expression level of PEDF reached 0.721±0.314. While patients in Group B the expression level of PEDF was only 0.538±0.253. Two groups had significant difference between the expression level of PEDF(P
ISSN:1672-5123
1672-5123
DOI:10.3980/j.issn.1672-5123.2017.8.11