Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong

Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong

We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025...

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Veröffentlicht in:Emerging infectious diseases 2021-12, Vol.27 (12), p.3036-3044
Hauptverfasser: Guo, Cosmos L T, Kwong, Thomas N Y, Mak, Joyce W Y, Zhang, Lin, Lui, Grace C Y, Wong, Grace L H, Ip, Margaret, Yu, Jun, Sung, Joseph J Y, Wu, William K K, Wong, Sunny H
Format: Artikel
Sprache:eng
Schlagworte:
Age
Antibiotics
antimicrobial resistance
Clinical outcomes
Clostridioides difficile
Clostridium infections
Clostridium Infections - diagnosis
Clostridium Infections - epidemiology
Disease
Drug use
Epidemics
Epidemiology
Health facilities
Hong Kong
Hong Kong - epidemiology
Hospital patients
Hospitalization
Humans
Incidence
Infection, Hong Kong
Laboratories
Mortality
Patient outcomes
Patients
pseudomembranous colitis
Regression analysis
Risk factors
Statistics
surveillance
Trends in Incidence and Clinical Outcomes of
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Beschreibung
Zusammenfassung:We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at ≈11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2712.203769