Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more assoc...

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Veröffentlicht in:	Mediators of inflammation 2017-01, Vol.2017 (2017), p.1-8
Hauptverfasser:	Park, Hae-Sim, Jung, Chang-Gyu, Choi, Youngwoo, Park, Hanki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin Aspirin - therapeutic use Asthma Asthma - blood Asthma - drug therapy Asthma - immunology Asthma, Aspirin-Induced - blood Asthma, Aspirin-Induced - drug therapy Asthma, Aspirin-Induced - immunology Biomarkers Biomarkers - blood Biomarkers - metabolism Complications and side effects Cyclooxygenase-1 Cytokines Diagnosis Genomics Humans Hypersensitivity Immunology Lipids Nonsteroidal anti-inflammatory drugs Phenotypes Polyps Respiration Disorders - blood Respiration Disorders - drug therapy Respiration Disorders - immunology Respiratory diseases Respiratory tract diseases Review Rhinosinusitis Risk factors Urine
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Beschreibung
Zusammenfassung:	Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2017/8160148