In Vivo Evaluation of Hydroxyapatite Foams

Porous hydroxyapatite manufactured by foaming of aqueous ceramic suspensions and setting via gelcasting of organic monomers was tested for in-vivo biocompatibility in rabbit tibia for a period of 8 weeks. The foams provide frameworks and large interconnected pores that support cell attachment and organisation into 3D arrays to form new tissue. The HA foam implants were progressively filled with mature bone tissue and osteoid after the implanted period, confirming the high osteoconductive potential and high biocompatibility of HA and the suitability of foam network in providing good osteointegration. No immune or inflammatory reactions were detected. 9 refs.