Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the desig...

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Veröffentlicht in:	PloS one 2012, Vol.7 (8), p.e35234-e35234
Hauptverfasser:	Li, Lin, Chang, Shenghai, Xiang, Junfeng, Li, Qian, Liang, Huanhuan, Tang, Yalin, Liu, Yingfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology DNA-Directed RNA Polymerases - antagonists & inhibitors Drug Design Drug Evaluation, Preclinical Humans Influenza A Virus, H5N1 Subtype - enzymology Magnetic Resonance Spectroscopy Quinic Acid - analogs & derivatives Quinic Acid - chemistry Viral Proteins - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0035234