NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer

NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer

Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever reported. W...

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Veröffentlicht in:Scientific reports 2021-05, Vol.11 (1), p.11125-11125, Article 11125
Hauptverfasser: Marchetti, Claudia, D’Indinosante, Marco, Bottoni, Carolina, Di Ilio, Chiara, Di Berardino, Stefano, Costantini, Barbara, Minucci, Angelo, Vertechy, Laura, Scambia, Giovanni, Fagotti, Anna
Format: Artikel
Sprache:eng
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631/67/1517
631/67/1517/1709
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
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Zusammenfassung:Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever reported. We consecutively enrolled a series of 397 newly diagnosed high-grade serous-advanced OC-patients. All patients were tested for BRCA-mutational-status and blood-parameters have been collected 48 h before staging-surgery. A significant correlation of NLR with disease distribution (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90361-w