The Relationship Between Diabetic Peripheral Neuropathy and (MPV) Mean Platelet Volume Values in Patients With Type 2 Diabetes Mellitus

Aim:We aimed to evaluate the relationship between diabetic peripheral neuropathy and MPV values in type 2 diabetes mellitus patients.Materials and Methods:We investigated type 2 diabetic patients’ data retrospectively. The data was divided as two groups (with and without diabetic peripheral neuropathy) according to their history, physical examination, laboratory results and electro-physiological study results. The patients with cardiovascular, hematological, oncological, hepatic, renal, infectious disease or a recent history of trauma and surgery were excluded. Statistical analysis was studied by SPSS 21 soft-ware statistics programme.Results:We included 83 diabetic patients (ages between 31 and 76) that 39 of them were patients with diabetic peripheral neuropathy (25 women, 14 men) and 44(27 women, 17 men) were without neuropathy. While the means of non-neuropathic group for the age was 57,89±8,8(31-75), A1c 7,3%(5,5-12,7), platelet counts 260.800±68,900/mm3, MPV value 8,96±0,67 fl(7,6-10,4); the means of neuropathic group were 56,54±8,4(37-76) years, 8,3 (5,6-14,4)%, 269.050±74.195/mm3 and 9,03 ± 0,75(7,4-10,5) fl respectively. There were no statistically significant differences in terms of age(p=0,482), platelet count(p=0,601), body mass index(p=0,299), MPV(p=0,596) and A1c(p=0,076). But statistically significant differences were found in terms of diabetes age(p=0,002) and fasting plasma glucose(p=0,04). A statistically significant correlation was not found between MPV and neuropathy existence by Spearman correlation analysis(p=0,599).Conclusion:We didn't find any correlation between MPV value and neuropathy development in our study. We suggest that to clarify this relationship certainly, we need a prospective, multi-centered study with a bigger cohort.