Effects of Zearalenone on IL-2, IL-6, and IFN-γ mRNA Levels in the Splenic Lymphocytes of Chickens

Zearalenone (ZEN) is an estrogenic mycotoxin produced by several Fusarium species, which can contaminate food and feed. These compounds elicit a wide spectrum of toxic effects, including the capacity to alter normal immune function. In this study, the in vitro effects of the treatment of ConA-stimul...

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Veröffentlicht in:	TheScientificWorld 2012-01, Vol.2012 (2012), p.1-5
Hauptverfasser:	Wang, Y. C., Deng, J. L., Xu, S. W., Peng, X., Zuo, Z. C., Cui, H. M., Wang, Y., Ren, Z. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chickens Concanavalin A Cytokines Estrogens, Non-Steroidal - pharmacology Food contamination Gene expression Gene Expression Regulation - drug effects Genetic aspects Health aspects Immune response Immune System Interferon-gamma - biosynthesis Interleukin 2 Interleukin 6 Interleukin-2 - biosynthesis Interleukin-6 - biosynthesis Interleukins Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Messenger RNA Models, Biological mRNA Mycotoxins Physiological aspects RNA, Messenger - biosynthesis Spleen Statistical analysis Statistical significance Toxins Xenoestrogens Zearalenone Zearalenone - pharmacology
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Zusammenfassung:	Zearalenone (ZEN) is an estrogenic mycotoxin produced by several Fusarium species, which can contaminate food and feed. These compounds elicit a wide spectrum of toxic effects, including the capacity to alter normal immune function. In this study, the in vitro effects of the treatment of ConA-stimulated splenic lymphocytes with ZEN (0–25 μg/mL) were examined. ZEN modulates the expression of IL-2, IL-6, and IFN-γ. The IL-2 levels were up to fourfold higher (P
ISSN:	2356-6140 1537-744X 1537-744X
DOI:	10.1100/2012/567327