Roles of Triggering Receptor Expressed on Myeloid Cells-1: More than Just Pneumonia
Triggering receptor expressed on myeloid cells (TREM)-1 is a transmembrane receptor embedded in the intrinsic immune cell membrane that amplifies inflammation by increasing inflammatory signalling triggered by toll-like receptors as well as transcript levels in the NF-κB signalling pathway. The solu...
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Veröffentlicht in: | Advances in human biology 2024-01, Vol.14 (1), p.18-24 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Triggering receptor expressed on myeloid cells (TREM)-1 is a transmembrane receptor embedded in the intrinsic immune cell membrane that amplifies inflammation by increasing inflammatory signalling triggered by toll-like receptors as well as transcript levels in the NF-κB signalling pathway. The soluble form of TREM-1 is obtained by cleavage of the extracellular portion of TREM-1 by matrix metalloprotease-9 and can be used as a biomarker for the diagnosis and prognosis of TREM-1 pathway activation in many acute and chronic inflammatory diseases. The present review aims to summarise the latest research and insights on TREM-1 in inflammatory and non-inflammatory diseases. |
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ISSN: | 2321-8568 2348-4691 |
DOI: | 10.4103/aihb.aihb_173_22 |