Roles of Triggering Receptor Expressed on Myeloid Cells-1: More than Just Pneumonia

Triggering receptor expressed on myeloid cells (TREM)-1 is a transmembrane receptor embedded in the intrinsic immune cell membrane that amplifies inflammation by increasing inflammatory signalling triggered by toll-like receptors as well as transcript levels in the NF-κB signalling pathway. The solu...

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Veröffentlicht in:Advances in human biology 2024-01, Vol.14 (1), p.18-24
Hauptverfasser: Han, Jiajia, Li, Li
Format: Artikel
Sprache:eng
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Zusammenfassung:Triggering receptor expressed on myeloid cells (TREM)-1 is a transmembrane receptor embedded in the intrinsic immune cell membrane that amplifies inflammation by increasing inflammatory signalling triggered by toll-like receptors as well as transcript levels in the NF-κB signalling pathway. The soluble form of TREM-1 is obtained by cleavage of the extracellular portion of TREM-1 by matrix metalloprotease-9 and can be used as a biomarker for the diagnosis and prognosis of TREM-1 pathway activation in many acute and chronic inflammatory diseases. The present review aims to summarise the latest research and insights on TREM-1 in inflammatory and non-inflammatory diseases.
ISSN:2321-8568
2348-4691
DOI:10.4103/aihb.aihb_173_22