Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation

To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB 1 ) and 2 (CB 2 ) receptors attenuate cancer-induced bone pain, we searched Medline, Web of Science and Scopus for relevant skeletal and non-skeletal cancer studies from inception to July 28, 2...

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Veröffentlicht in:Scientific reports 2024-03, Vol.14 (1), p.5782-5782, Article 5782
Hauptverfasser: Zeng, Feier, Wade, Abbie, Harbert, Kade, Patel, Shrina, Holley, Joshua S., Dehghanpuor, Cornelia K., Hopwood, Thomas, Marino, Silvia, Sophocleous, Antonia, Idris, Aymen I.
Format: Artikel
Sprache:eng
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Agonists
Analgesics
Animal models
Animals
Bioinformatics
Bone
Bone cancer
Cancer
Cancer Pain - drug therapy
Cancer Pain - etiology
Cannabinoid CB1 receptors
Cannabinoid CB2 receptors
Cannabinoid Receptor Agonists
Cannabinoids - pharmacology
Cannabinoids - therapeutic use
Cannabis
CB1
CB2
Genetic engineering
Humanities and Social Sciences
Humans
Immunomodulation
Inflammation
Latency
Male
Males
Meta-analysis
Mice
multidisciplinary
Neoplasms - drug therapy
Osteolysis
Osteolysis - drug therapy
Pain
Pain perception
Patients
Plants
Rats
Receptor, Cannabinoid, CB1
Receptor, Cannabinoid, CB2
Receptors, Cannabinoid
Science
Science (multidisciplinary)
Tetrahydrocannabinol
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Zusammenfassung:To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB 1 ) and 2 (CB 2 ) receptors attenuate cancer-induced bone pain, we searched Medline, Web of Science and Scopus for relevant skeletal and non-skeletal cancer studies from inception to July 28, 2022. We identified 29 animal and 35 human studies. In mice, a meta-analysis of pooled studies showed that treatment of osteolysis-bearing males with the endocannabinoids AEA and 2-AG (mean difference [MD] − 24.83, 95% confidence interval [ 95% CI] − 34.89, − 14.76, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-56220-0