Histological Alterations in Placentas of Pregnant Women with SARS-CoV-2 Infection: A Single-Center Case Series

This study aimed to investigate the histopathological changes associated with SARS-CoV-2 infection in placentas. A case series of anatomopathological analysis was conducted on the placentas of pregnant women with SARS-CoV-2 who delivered between March and December 2020 at Santo Amaro Hospital (HSA) in Salvador, Brazil. Out of the 29 placentas examined, the median weight was 423.0 (IQR: 385.0-521.0) g. Among them, 58.3% ( = 14) had inadequate weight relative to the newborn's weight. The histopathological findings revealed that 86.2% ( = 25) of the placentas had poorly defined lobes, and the fetal and maternal surface color was normal in 89.7% ( = 26) and 93.1% ( = 27), respectively. Additionally, 51.7% ( = 15) of the umbilical cords displayed hypercoiling. The most frequent microscopic finding was infarction, present in 35.3% ( = 6) of the cases, followed by 11.8% ( = 2) for each of chorioamnionitis, chronic villitis, focal perivillositis, and laminar necrosis. Analysis of the umbilical cords identified 23.5% ( = 4) cases of intervillous thrombosis, while amnion analysis showed 13.8% ( = 4) cases of squamous metaplasia. Extraplacental membrane examination revealed fibrin deposition in 93.1% ( = 27) of the cases, necrosis in 62.0% ( = 18), calcifications in 51.7% ( = 15), cysts in 37.9% ( = 11), neutrophilic exudate in 17.2% ( = 5), thrombosis in 13.7% ( = 4), and delayed placental maturation in 6.9% ( = 2). All analyzed placentas exhibited histopathological changes, primarily vascular and inflammatory, which indicate SARS-CoV-2 infection in term pregnancies. These alterations could be associated with impaired placental function, fetal growth restriction, preeclampsia, and prematurity. However, further prospective studies are required to validate the type, prevalence, and prognosis of each of these changes.