Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study

Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study

Highlights • Teriparatide (TPTD) and fracture healing studies in premenopausal women is limited. • Brief TPTD administration showed a greater anabolic window compared to placebo. • Bone formation markers increased in TPTD- vs. placebo-treated group (both p ≤ 0.01). • TPTD (83.3%) vs. placebo (57.1%)...

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Veröffentlicht in:Journal of clinical & translational endocrinology 2016-09, Vol.5 (C), p.7-14
Hauptverfasser: Almirol, Ellen A, Chi, Lisa Y, Khurana, Bharti, Hurwitz, Shelley, Bluman, Eric M, Chiodo, Christopher, Matzkin, Elizabeth, Baima, Jennifer, LeBoff, Meryl S
Format: Artikel
Sprache:eng
Schlagworte:
Anabolic window
Endocrinology & Metabolism
Pilot study
Premenopausal
Research Paper
Stress fracture
Teriparatide
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Zusammenfassung:Highlights • Teriparatide (TPTD) and fracture healing studies in premenopausal women is limited. • Brief TPTD administration showed a greater anabolic window compared to placebo. • Bone formation markers increased in TPTD- vs. placebo-treated group (both p ≤ 0.01). • TPTD (83.3%) vs. placebo (57.1%) showed improved stress fractures on MRI (p = 0.18).
ISSN:2214-6237
2214-6237
DOI:10.1016/j.jcte.2016.05.004