The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there...

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Veröffentlicht in:	International journal of molecular sciences 2022-01, Vol.23 (2), p.807
Hauptverfasser:	Delrue, Charlotte, Speeckaert, Reinhart, Delanghe, Joris R, Speeckaert, Marijn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Calciferol Clinical Studies as Topic Diabetes Diabetes mellitus Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Diabetic nephropathy Disease Disease Management Disease Models, Animal Disease Susceptibility Extracellular matrix Gene Expression Regulation - drug effects Genes Genetic Predisposition to Disease Health care Humans Hyperglycemia Insulin resistance Kidney diseases Kidneys Metabolism Metabolites Nephropathy Oxidative stress Proteins Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Review Translation Translational Research, Biomedical Vitamin D Vitamin D - metabolism Vitamin D - pharmacology Vitamin D - therapeutic use Vitamin D Deficiency - complications Vitamin D Deficiency - etiology Vitamin D Deficiency - metabolism Vitamin deficiency
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Zusammenfassung:	According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23020807