Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

Protein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME, 6 with pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2021-05, Vol.11 (1), p.10449-9, Article 10449
Hauptverfasser: Sugimoto, Masahiko, Kondo, Mineo, Yasuma, Taro, D’Alessandro-Gabazza, Corina N., Toda, Masaaki, Imai, Hisanori, Nakamura, Makoto, Gabazza, Esteban C.
Format: Artikel
Sprache:eng
Schlagworte:
692/699/2743/137/138
692/699/3161
Aged
Aged, 80 and over
Aqueous Humor - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - etiology
Diabetic Retinopathy - pathology
Diabetic Retinopathy - surgery
Edema
Enzyme immunoassay
Eye
Female
Humanities and Social Sciences
Humans
Immunohistochemistry
Lesions
Macular Edema - diagnosis
Macular Edema - etiology
Macular Edema - pathology
Macular Edema - surgery
Male
Middle Aged
multidisciplinary
Protein S
Protein S - analysis
Protein S - metabolism
Retina
Retina - diagnostic imaging
Retina - metabolism
Retina - pathology
Retina - surgery
Retinopathy
Science
Science (multidisciplinary)
Severity of Illness Index
Surgery
Tomography, Optical Coherence
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Protein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME, 6 with proliferative DR, and 7 with no DR) and 19 eyes without DM. The level of PS was measured by enzyme immunoassay and was compared between eyes with or without DM, with or without DME, and with severe DME (≥ 350 μm) or mild DME (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-89870-5