The anti-diabetic and antioxidant effects of a combination of Commiphora mukul , Commiphora myrrha and Terminalia chebula in diabetic rats

Effects of and ethanolic extracts and hydro-ethanolic extract combination were evaluated in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats (n=48) were randomly assigned into: control; diabetic; diabetic+metformin (300 mg/kg); diabetic+dose 1 of herbal combination (438 mg/kg of +214 mg/kg of +857 mg/kg of ); diabetic+dose 2 (642 mg/kg of +214 mg/kg of +642 mg/kg of ); and diabetic+dose 3 (857 mg/kg of +438 mg/kg of +1714 mg/kg t of ). All treatments were given orally by gavage. Diabetes was induced by STZ (60 mg/kg, i.p.). At the end of study (day 28), blood glucose, insulin and lipid profile; as well as hepatic malondialdehyde (MDA) and thiol content, and superoxide dismutase (SOD) and catalase (CAT) activities were determined. In diabetic rats, plasma glucose, triglycerides (TG), total cholesterol (TC), and LDL-C, as well as hepatic MDA levels were elevated but plasma HDL-C and insulin, and hepatic thiol content and SOD and CAT activities were reduced compared to control (p