The protective effect of allium cepa against ethylene glycol-induced kidney stones in rats

Kidney stones is one of the serious medical conditions affecting populations worldwide. So, we aimed in this study to investigate the protective effect of allium cepa administration against KSD. 24 adult male albino rats were assigned into 3 groups; group I: control group; group II: received ethylen...

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Veröffentlicht in:Heliyon 2023-11, Vol.9 (11), p.e21221-e21221, Article e21221
Hauptverfasser: Wahid, Reham M., Hassan, Nancy Husseiny, Samy, Walaa, Faragallah, Eman Mahmoud, El-Malkey, Nanees F., Talaat, Aliaa, Ghoneum, Alia, Aldisi, Dara, Malek, Mahmoud M.
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Sprache:eng
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Zusammenfassung:Kidney stones is one of the serious medical conditions affecting populations worldwide. So, we aimed in this study to investigate the protective effect of allium cepa administration against KSD. 24 adult male albino rats were assigned into 3 groups; group I: control group; group II: received ethylene glycol (EG) in the drinking water for 4 weeks; and group III received EG in the drinking water plus freshly prepared allium cepa extract (ACE) for 4 weeks. Renal function tests and urine analysis were done. Tissue oxidative stress markers (SOD and MDA) were assessed, and kidney expression of SIRT-1, Beclin, LC3, osteopontin, and Regucalcin were measured by RT-qPCR. Histopathological assessment and immunohistochemistry for Bax, Beclin-1 and TNF-α were performed. There was a significant improved kidney function tests in the ACE received group compared to EG group (P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e21221