A novel scale based on biomarkers associated with COVID-19 severity can predict the need for hospitalization and intensive care, as well as enhanced probabilities for mortality

Prognostic scales may help to optimize the use of hospital resources, which may be of prime interest in the context of a fast spreading pandemics. Nonetheless, such tools are underdeveloped in the context of COVID-19. In the present article we asked whether accurate prognostic scales could be develo...

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Veröffentlicht in:Scientific reports 2023-06, Vol.13 (1), p.9064-9064, Article 9064
Hauptverfasser: Nieto-Ortega, Eduardo, Maldonado-del-Arenal, Alejandro, Escudero-Roque, Lupita, Macedo-Falcon, Diana Ali, Escorcia-Saucedo, Ana Elena, León-del-Ángel, Adalberto, Durán-Méndez, Alejandro, Rueda-Medécigo, María José, García-Callejas, Karla, Hernández-Islas, Sergio, Romero-López, Gabriel, Hernández-Romero, Ángel Raúl, Pérez-Ortega, Daniela, Rodríguez-Segura, Estephany, Montaño‑Olmos, Daniela, Hernández-Muñoz, Jeffrey, Rodríguez-Peña, Samuel, Magos, Montserrat, Aco-Cuamani, Yanira Lizeth, García-Chávez, Nazareth, García-Otero, Ana Lizeth, Mejía-Rangel, Analiz, Gutiérrez-Losada, Valeria, Cova-Bonilla, Miguel, Aguilar-Arroyo, Alma Delia, Sandoval-García, Araceli, Martínez-Francisco, Eneyda, Vázquez-García, Blanca Azucena, Jardínez-Vera, Aldo Christiaan, del Campo, Alejandro Lechuga-Martín, Peón, Alberto N.
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Sprache:eng
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Zusammenfassung:Prognostic scales may help to optimize the use of hospital resources, which may be of prime interest in the context of a fast spreading pandemics. Nonetheless, such tools are underdeveloped in the context of COVID-19. In the present article we asked whether accurate prognostic scales could be developed to optimize the use of hospital resources. We retrospectively studied 467 files of hospitalized patients after COVID-19. The odds ratios for 16 different biomarkers were calculated, those that were significantly associated were screened by a Pearson’s correlation, and such index was used to establish the mathematical function for each marker. The scales to predict the need for hospitalization, intensive-care requirement and mortality had enhanced sensitivities (0.91 CI 0.87–0.94; 0.96 CI 0.94–0.98; 0.96 CI 0.94–0.98; all with p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30913-4