Blood cell traits and venous thromboembolism in East Asians: Observational and genetic evidence

Blood cell traits and venous thromboembolism in East Asians: Observational and genetic evidence

Previous studies have indicated that various blood cell traits are associated with a higher risk of venous thromboembolism (VTE). However, the causal relationship remains uncertain. We collected data from the China pulmonary thromboembolism registry study and the China pulmonary health study, using...

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Veröffentlicht in:iScience 2024-09, Vol.27 (9), p.110671, Article 110671
Hauptverfasser: Li, Haobo, Duo, Mengjie, Zhang, Zhu, Weng, Haoyi, Liu, Dong, Zhang, Yu, Xi, Linfeng, Zou, Bingzhang, Li, Huiwen, Chen, Gang, Zuo, Xianbo, Ito, Kaoru, Xie, Wanmu, Yang, Peiran, Wang, Chen, Zhai, Zhenguo
Format: Artikel
Sprache:eng
Schlagworte:
Cardiovascular medicine
Clinical genetics
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Zusammenfassung:Previous studies have indicated that various blood cell traits are associated with a higher risk of venous thromboembolism (VTE). However, the causal relationship remains uncertain. We collected data from the China pulmonary thromboembolism registry study and the China pulmonary health study, using propensity score matching and two-sample Mendelian randomization analyses with summary statistics from genome-wide association studies of blood cell traits and VTE in the East Asian population. Our findings revealed that platelet (PLT) count and hemoglobin (Hb) levels were significantly higher in VTE patients compared to the general population (p value
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.110671