Leucine-Rich Immune Factor APL1 Is Associated With Specific Modulation of Enteric Microbiome Taxa in the Asian Malaria Mosquito Anopheles stephensi
The commensal gut microbiome is contained by the enteric epithelial barrier, but little is known about the degree of specificity of host immune barrier interactions for particular bacterial taxa. Here, we show that depletion of leucine-rich repeat immune factor APL1 in the Asian malaria mosquito is...
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Veröffentlicht in: | Frontiers in microbiology 2020-02, Vol.11, p.306-306 |
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Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The commensal gut microbiome is contained by the enteric epithelial barrier, but little is known about the degree of specificity of host immune barrier interactions for particular bacterial taxa. Here, we show that depletion of leucine-rich repeat immune factor APL1 in the Asian malaria mosquito
is associated with higher midgut abundance of just the family
, and not generalized dysbiosis of the microbiome. The effect is explained by the response of a narrow clade containing two main taxa related to
and
. Analysis of field samples indicate that these two taxa are recurrent members of the wild
microbiome. Triangulation using sequence and functional data incriminated relatives of
and
NFIX57 as candidates for the
component, and
,
, and
LTGPAF-6F as candidates for the
component. APL1 presence is associated with host ability to specifically constrain the abundance of a narrow microbiome clade of the
, and the immune factor may promote homeostasis of this clade in the enteric microbiome for host benefit. |
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ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2020.00306 |