Case of successful use of sarilumab in secondary renal amyloidosis in a patient with rheumatoid arthritis

Clinical observation of the successful use of the interleukin 6 (IL6) inhibitor sarilumab in secondary renal amyloidosis in a patient with active seropositive rheumatoid arthritis, is presented. This complication was confirmed by biopsy of rectum. The presented clinical example demonstrates a fairly...

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Veröffentlicht in:Nauchno-prakticheskai͡a︡ revmatologii͡a 2022-11, Vol.60 (5), p.599-602
Hauptverfasser: Smirnova, L. A., Simonova, O. V., Sukhikh, E. N., Shilyaeva, A. O.
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Sprache:eng
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Zusammenfassung:Clinical observation of the successful use of the interleukin 6 (IL6) inhibitor sarilumab in secondary renal amyloidosis in a patient with active seropositive rheumatoid arthritis, is presented. This complication was confirmed by biopsy of rectum. The presented clinical example demonstrates a fairly rapid, within five years from the onset of the disease, the development of secondary renal amyolidosis with the formation of a persistent nephrotic syndrome that is resistant to therapy with cyclophosphamide and rituximab. Prescription of the IL6 inhibitor tocilizumab contributed to a decrease in the clinical and laboratory activity of the underlying disease, a decrease in the severity of daily proteinuria, but did not allow to achieve the full effect. The use of another IL6 inhibitor – sarilumab, led to a complete regression of nephrotic syndrome with normalization of general urine analysis, biochemical blood tests – total protein, albumin, total cholesterol, against the background of stable clinical and laboratory remission of rheumatoid arthritis.
ISSN:1995-4484
1995-4492
DOI:10.47360/1995-4484-2022-599-602