Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation

Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation

Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly responsive to mechanical stimulation by permitting...

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Veröffentlicht in:Frontiers in cell and developmental biology 2023-04, Vol.11, p.1151838
Hauptverfasser: Zhao, Dezhi, Wu, Jiawei, Acosta, Francisca M., Xu, Huiyun, Jiang, Jean X.
Format: Artikel
Sprache:eng
Schlagworte:
bone
Cell and Developmental Biology
connexin 43
hemichannel
mechanical stimulation
prostaglandin E2
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Zusammenfassung:Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly responsive to mechanical stimulation by permitting the exchange of small molecules (
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2023.1151838