Guided Wrinkling of Hierarchically Structured Nanoporous Gold Films for Improved Surface‐Enhanced Raman Scattering Performance

Plasmonic nanostructured metals have many advantages for applications in high‐performance surface‐enhanced Raman scattering (SERS) spectroscopy. In particular, unique designing nanostructures with bicontinuous ligaments surrounded by cylindrical voids with tunable dense pores from a few to hundreds of nanometers can be utilized for the high‐performance SERS‐active substrate. Here, a fabrication strategy is reported to prepare hierarchically arranged micro/nanostructures of wrinkled nanoporous gold (WNPG) films, which involves laminating of the dealloyed Au film on the heat‐shrinkable shape‐memory polymer film and geometrical modulation of the substrate. As a result, the various types of WNPG films are crafted with a remarkable density of cracks in the structured surface area. Specifically, the WNPG films consisting of multilayered overlapping features are explored and used as the SERS‐active substrate. This dual porosity coupled with localized surface plasmon resonance estimated by numerical simulation in a suitable model of bicontinuous ligaments is found to be the core mechanism for the enhancement of SERS sensitivity, which quantitatively characterizes the “hot spots” from the surface to interlayers. These suggested characteristic features are fully assessed by applying a series of dye molecules and DNA strands on the prepared SERS substrate, demonstrating the enhanced intensity of the Raman scattering signals on the optimized WNPG surface. Hierarchically arranged micro/nanostructures of wrinkled nanoporous gold films are crafted by utilizing simple guidance with a heat‐shrinkable shape‐memory polymer film. The multilayer overlapping feature of dual porosity coupled with a “hot spot” in the quasi‐periodic structure is explored using 3D mesh model simulation and demonstrates a surface‐enhanced Raman detection of DNA hybridization.